Mesopotamia is a region of Southwest Asia. Writings from Mesopotamia (Uruk, modern Warka) are among the earliest known in the world, giving Mesopotamia a reputation of being the "Cradle of Civilization". The age of Sumerian writing is about on a par with Egyptian hieroglyphs, and some yet older inscriptions are known, probably ranking as proto-writing (Old European script, Naqada
City states and Imperial glory:-
Mesopotamia was settled, and conquered, by numerous ancient civilizations:
Mesopotamia was home to some of the oldest major ancient civilizations, including the Sumerians, Akkadians, Babylonians and Assyrians.
In 5000 BC, the Sumerians arrived in Mesopotamia. The Semites arrived in 2900 BC and by 2000 BC they had mixed peacefully with the Sumerians and had assumed political dominance.
The region ceased to be a major power house since its inclusion in the Persian Empire of the Achaemenids, apparently as two satrapies, Babylonia in the south and Athura (from Assyria) in the north.
After the conquest of all Persia by the Hellenizing Macedonian king Alexander the Great, the satrapies were part of the major diadochy, the Seleucid Empire, almost until its elimination by Greater Armenia in 42 BC.
Most of Mesopotamia then became part of the Parthian Empire of the Arsakides.
However part, in the northwest, became Roman. Under the Tetrarchy, this was divided into two provinces, called Osrhoene (around Edessa; roughly the modern-day border between Turkey and Syria) and Mesopotamia (a bit more northeast).
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